Hi Reader,

This month, we’re unpacking the current evidence behind some common blister prevention strategies. Some methods hold up under scrutiny, while others don’t have the science to back them. If you’ve ever wondered what truly works and what might be wasting your time, this will help you cut through the noise.

I hope you enjoy this one!

Rebecca

✅ EVIDENCE FOR

Cushioning Insoles

There are a couple of studies that show a clear reduction in blister incidence when 3mm Spenco® insoles are used. In one study of 200 athletes, only 0.5% developed blisters with a Spenco® insole, compared to 25% in the control. Another study comparing neoprene (Spenco®), polyurethane (Poron®), and no insole found Spenco® to be the most effective, with just 1 blister reported versus 4 and 8 in the other groups.

Spenco® insoles stand out. Their success may be due to a combination of shear absorption, pressure reduction, and lower friction (coefficient of friction). These findings make Spenco® one of the few blister prevention methods with clear supporting evidence.

👉🏻 Click this link or the image below to view the data full scale.

🚫 EVIDENCE AGAINST

Antiperspirants

Despite their popularity, antiperspirants are not supported by evidence as an effective blister prevention method. Multiple studies—including large trials with military personnel—found no meaningful reduction in blister incidence, and in many cases, they increased skin irritation. When irritant ingredients like aluminum salts were used, skin reaction rates were as high as 57%, offsetting any small protective effect.

When emollients were added to reduce irritant dermatitis, the blister prevention effect was lost. The takeaway: while the idea of keeping skin dry sounds logical, antiperspirants are not an effective way of achieving blister prevention.

👉🏻 Click this link or the image below to view the research summary in full.

⚠️ NO EVIDENCE

Strategies Lacking Research Support

While many blister prevention products and techniques are widely used, there is currently no published evidence supporting their effectiveness. This doesn’t mean they don’t work; it simply means they haven’t been studied in a way that confirms their benefit.

• Lubricants
• Rigid tape, Fixomull Stretch, Kinesio Tape, Moleskin
• Pressure-deflective padding
• Optimised shoe-fit
• Toesocks
• Specific sock yarns, fibres, blends
• Specific sock constructions (other than thickness/dense padding)
• PTFE Patches / ENGO Patches / Shearban
• PelliTec Pads
• Gel toe protectors
• Digital orthoses (eg: toeprops)
• Biomechanical interventions (eg: orthoses, strengthening, stretching)
• Gait alterations

OFFICE HOURS

Evidence-Based Prevention Strategies

This month’s Office Hours session explored the current evidence base for blister prevention strategies. From powders and antiperspirants to insoles, tapes, socks, orthotics, and more, we looked at what the research supports and what it doesn’t.

The session also covered how to approach clinical decision-making when evidence is limited, offering practical guidance for navigating uncertainty in blister prevention.
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​🎥 Watch the replay here: What Is The Current Evidence Base For Blister Prevention Strategies?​

PARTNER WITH US FOR FREE!

Spenco Insoles

3mm Spenco (neoprene) insoles are one of the few blister prevention strategies supported by clinical evidence. Their soft, springy neoprene layer helps cushion the foot and absorb the shear forces that lead to blister formation.

If your patient continues to suffer with plantar blisters, ta Spenco insole (or Spenco orthotic cover) are a proven blister prevention intervention.

✅ Clinically supported
✅ Reduces shear
✅ Ideal for plantar blisters

As a Blister Prevention Wholesale Partner, you can:

• Stock 3mm Spenco insoles at exclusive wholesale rates
• Offer your patients a science-informed solution—not myths!
• Join for free and start maximising your margins

Becoming a Blister Prevention Wholesale Partner is completely free! Join the growing network of practitioners who are enhancing their blister care offerings while maintaining healthy margins.

Sign up to Blister Prevention Wholesale here.

BLISTER PREVENTION

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